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The provider must document that CKD causes the anemia

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Although the clinical effect of l-asparaginase clearly indicates that asparagine is crucial for tumor survival and metastasis 52 , the importance of asparagine beyond protein synthesis and the mechanism by which asparagine supplementation enhances glutamine-associated metabolism are less well understood

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serves on advisory boards of Sanofi Aventis and Merck Sharp & Dohme (all honoraria paid to employer)

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