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GLP-1 receptor agonists work by mimicking the action of naturally occurring GLP-1, a hormone that stimulates insulin secretion in response to food intake, suppresses glucagon release, slows gastric emptying, and promotes satiety
Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ
So we want their insulin sensitive
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IGF-1R expression predicts clinical outcome in patients with locally advanced oral squamous cell carcinoma
Activates longevity genes like FOXO3, linked to extended lifespan
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