Thus, for a female, the multiplier S will vary between 1.104 to 3.31 and E 2 = 0.4368 nM
4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (1, 139)
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10.1530/JOE-11-0328 J