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doi: 10.1080/07391102.2014.954272 93 MatsuokaK.NishiumiS.YoshidaM.KodamaY
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The binding of C-Met to HGF initiates the receptors innate kinase activity, followed by the formation of a multisubstrate docking site for the intracellular junction protein, which recruits signaling molecules due to homologous dimerization and autophosphorylation at Tyr1234 and Tyr1235 and subsequent phosphorylation at Tyr1349 and Tyr1356 at the c-terminal tail (Birchmeier et al., 2003
Wang H, Chang H, Sun D, Wang A, Yan B, Chung E
If "stronger" means more familiar biology, a clearer bridge from an already-approved GLP-1 backbone, and a less radical product concept, CagriSema looks stronger
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