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Annals of the Royal College of Surgeons of England

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High levels are associated with heart disease, hardening of the arteries, diabetes, and colon cancer

Instead of barely filling a U-100 (1 milliliter) insulin syringe to draw a 5-unit (0.05 milliliter) dose some people have injected half the syringe, producing vomiting and other side effects

Additionally, berberines metabolites, such as berberrubine and palmatine, have been demonstrated to significantly enhance GLP-1 production and glucose-stimulated secretion in GLUTag cells, suggesting a complex metabolic interplay involving both the parent compound and its active derivatives (Weili Yang et al., 2024)

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