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If you look closely at the bottom panels of the 2 graphs above for loss of body weight, the participants in the new trial had 40% less weight loss than in the previous trial of obese, non-diabetic participants

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Blood sugar-lowering supplements: hypoglycemia risk Supplements that independently lower blood sugar, including ginseng, chromium picolinate, alpha-lipoic acid at high doses, and cinnamon extract, can compound the glucose-lowering effects of GLP-1 medications

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