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A pharmaceutical composition for intranasal administration, comprising an active ingredient and essential excipients, said active ingredient comprising 0.01% to 20% by weight (w/v) of semaglutide, or a pharmaceutically acceptable salt thereof, said pharmaceutical composition further comprising one or more permeation enhancers selected from a group consisting of cell penetrating peptides, tight junction modulating agents, and bioadhesive agents

It's derived from common plants such as cinnamon, mint, citrus, and lavender

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Common Side Effects Nausea and vomiting: The most frequently reported effects, especially at the beginning of treatment

If solubility is difficult, a small amount of dilute acetic acid (e.g., 0.1%) is commonly used in peptide labs to aid dissolution

Analysis was carried out in terms of fold change in lipid peroxidation level