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2.4 Microbiome-Endocrine integration (hours to days) Dysbiosis reshapes the bile-acid pool via microbial bile-salt hydrolase (BSH) activity, modulating farnesoid X receptor/Takeda G-protein-coupled receptor 5 (FXR/TGR5) signaling (preclinical), and microbiota-derived bile acids/short-chain fatty acids (SCFAs) can influence L-cell GLP-1 secretion, helping explain variability in subsequent postprandial responses (foundational preclinical listed in Supplementary Table S1
10.1097/ICO.0b013e31821dd986 143 TurkovicB.SikiricP.SeiwerthS.MiseS.AnicT.PetekM.et al (2004)
Cincinnati, OH: National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention
Maloney RC, Zhang M, Liu Y, Jang H, Nussinov R (2022) The mechanism of activation of MEK1 by B-Raf and KSR1
To verify the loss of gGT expression by H
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