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Animal studies using euglycemic clamp techniques, the gold standard for insulin sensitivity assessment, confirmed that chronic AOD-9604 treatment produced no adverse effects on insulin sensitivity

Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

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This biochemical starvation directly contributes to the severe mood dysregulation, sleep disturbances, and the profound cognitive blankness often described by patients as brain fog