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Amgen's MariTide, which combines GLP-1 agonism with GIP antagonism, was specifically designed based on genetic evidence suggesting this combination could reduce nausea while maintaining weight loss efficacy [44]
The concern is that if you overstimulate melanocytes, particularly in someone who has an underlying tendency to skin cancer, you could increase the risk of melanoma developing. In addition, melanotan II often goes along with other risky sun-seeking behaviour such as sunbed usage, Dr Wedgeworth says
Avoid fried or fatty foods and dishes heavy on cheese, which can increase bloating, diarrhea and other GI symptoms
The two compounds work on entirely separate receptor systems and metabolic pathways
But, it hasn't given me any breakouts or comedones, which is a huge plus for my acne-prone/oily skin
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