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Injectable semaglutide 2.4 mg (Wegovy) produces somewhat greater weight loss than orforglipron: approximately 14.9% at 68 weeks in the STEP 1 trial versus 11.2% at 72 weeks with orforglipron 36 mg in ATTAIN-1
Heres a general breakdown of some common GLP-1 medications: Ozempic (semaglutide): Stays in your system for about 5-6 weeks after the last dose due to its long half-life of approximately 7 days per dose
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Evaluation of compliance with injection protocols and any barriers to consistent administration
Peak is medication-only on purpose
A safety signal worth noting is dysesthesia an abnormal sensation of touch, where normal sensations may feel unusual, tingling, or uncomfortable
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