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Serious Adverse Events and Discontinuation Signals In TRANSCEND-T2D-1, Lilly reported adverse-event discontinuation rates of 2.2%, 4.5%, and 5.1% with retatrutide 4 mg, 9 mg, and 12 mg, compared with 0.0% with placebo [9]
Pancreatitis or gallbladder problems are less common
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Moreover, this study reported that semaglutide had a lower economic spend than liraglutide for obesity management (56)
2017;15(3):e13249
Novo Nordisk combined semaglutide with an absorption enhancer called SNAC (sodium N- [8-(2-hydroxybenzoyl)amino] caprylate) which facilitates absorption in the stomach by increasing local pH and cell membrane permeability
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