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Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, et al
By slowly increasing the dose over this time frame, the likelihood of experiencing side effects (such as GI distress) is minimized
For instance, you could use your abdomen this week and your thigh the following week
Upregulated humoral factors, such as Midkine, further promote tubulointerstitial injury by accelerating local NETosis and subsequent tubular cell death (220)
If you want a broader overview of side effects during treatment, the article on tirzepatide side effects and what to expect is worth reading
Narrative review of metabolic syndrome and its relationships with non-alcoholic fatty liver disease, gonadal dysfunction and obstructive sleep apnea
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