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297 In particular, extracellular vesicle-mediated transfer of lncRNAs has been shown to activate MAPK signaling and reinforce chemoresistant states in HGSOC

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(1997) J Mol Biol 274 : 84-100 PubMed: 9398518 Search on PubMed DOI: Primary Citation Related Structures: 10GS, 5GSS, 6GSS, 7GSS, 8GSS, 9GSS PubMed Abstract: The human pi-class glutathione S-transferase (hGST P1-1) is a target for structure-based inhibitor design with the aim of developing drugs that could be used as adjuvants in chemotherapeutic treatment

Furthermore, it is being investigated for its potential use in chronic weight management, reducing the risk of major adverse cardiovascular events, and managing other conditions such as heart failure with preserved ejection fraction, obesity, and non-cirrhotic non-alcoholic steatohepatitis.The Phase 3 SURPASS 1-5 clinical trial program was conducted to evaluate the safety and effectiveness of tirzepatide, which was administered once weekly through subcutaneous injections at different doses (5, 10, and 15 mg)