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Both serum and plasma samples in which EDTA has been used as the anticoagulant can be used for all the B12 analytical methods

Firstly, this study only performed in vivo experiments

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Biomarkers can exist in the form of specific proteins, metabolites, genetic mutations, physiological parameters (e.g., blood pressure) or even brain imaging patterns that indicate a patients prognosis, in addition to the stage of disease pathogenesis and progression (Chen et al., 2011)

Since DNA replication stress can also be regulated by the redox status, we then measured ROS, GSSG, and reduced GSH in these cells