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Mechanisms of action and therapeutic application of glucagon-like Peptide-1

ABSTRACT: The past decade has brought several new developments in the treatment of type 2 diabetes, including the glucagon-like peptide-1 receptor agonists (GLP-1 RAs)

The pivotal STEP-1 trial reported approximately 14.9 percent mean body weight loss at 68 weeks on semaglutide

Depression, diabetes, comorbid depression and diabetes and risk of all-cause and cause-specific mortality: a prospective cohort study

Diabetes GLP-1s perform better but still leak demand: Diabetes-indicated GLP-1s show higher retention (24% at one year) and face fewer access hurdles due to broader coverage and disease framing, yet 76% of demand remains unmet

This is a 6.75 fold increased in percent weight loss from highest dose to placebo, compared to the 5.9 fold increase seen in the STEP-1 trial