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In study A, of the 12 participants who received at least one dose of 3 mg orforglipron, two participants (16.7%) experienced at least one TEAE in the fasted condition: two participants (16.7%) experienced nausea, one participant each (8.3%) experienced upper abdominal pain, dizziness, headache, oropharyngeal pain, sneezing, and vomiting (Table 5, Table S1 in Supplementary material)
Many foundational studies involved small numbers of subjects, appropriate for mechanistic pharmacology but insufficient for efficacy or safety conclusions
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In addition to helping participants control their blood sugar, liraglutide caused people to lose weight