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Individuals with red or blonde hair, freckling tendency, and minimal natural tanning ability produce predominantly pheomelanin (red-yellow pigment) rather than eumelanin (brown-black pigment)

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It activates several overlapping pathways, notably VEGFR2 and nitric oxide synthesis via the Akt-eNOS axis, promoting angiogenesis, fibroblast activity, and neuromuscular stabilization

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