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Intramuscular treatment can be necessary when the cause creates a persistent absorption problem, when specific surgery has removed the normal absorption pathway, or when clinical risk and adherence support that route

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And to do that all of the other delivery methods that could be used need to be thoroughly evaluated, not only as to their effectiveness in correcting the patients B12 Deficiency, but also in how the patient responds to particular delivery methods

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Higher plants do not concentrate methylcobalamin from the soil, making them a poor source of the substance as compared with animal tissues