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The CV effect of oral semaglutide for patients with T2D and ASCVD and/or chronic kidney disease (CKD) was investigated in the SOUL trial (NCT03914326)

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Glutamate then drives calcium influx through N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, as well as voltage-gated channels [2, 6]

These irregular periods often improve once your weight settles and your hormones stabilise again