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In the STEP-1 trial, Wegovy at 2.4 mg produced average weight loss of approximately 15 percent of body weight over 68 weeks
Through such effects, semaglutide also aids in reducing adipose tissue due to the forced mobilization of stored triglycerides for energy production
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Medical conditions affecting absorption warrant particular attention : Pernicious anaemia : an autoimmune condition destroying gastric parietal cells, requiring lifelong B12 injections Gastrointestinal surgery : particularly gastric bypass, gastrectomy, or terminal ileum resection Inflammatory bowel disease : Crohn's disease affecting the terminal ileum impairs absorption Coeliac disease : untreated disease damages the small intestine, reducing B12 uptake Medication use : long-term metformin therapy (MHRA safety alert) or nitrous oxide exposure Symptoms suggesting possible B12 deficiency include : persistent fatigue, weakness, paraesthesia (pins and needles) in hands or feet, glossitis (sore, red tongue), mood changes, memory problems, or unexplained anaemia
However, GLP-1 agonists are not indicated as primary therapy for hypogonadism, and patients with persistent symptoms should undergo appropriate endocrine evaluation
[1] [2] GLP-1 medications work by mimicking the action of naturally occurring incretin hormones produced in the intestine
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