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Synthetic DSIP was reported to cross the blood-brain barrier in early transport assays, supporting the idea that a peripherally administered compound could reach central targets

In terms of all MACE components together, we demonstrated that combination therapy was more effective than GLP-1RA monotherapy but not compared to SGLT-2i monotherapy

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GLP-1/GIP medications commonly cause nausea, vomiting, diarrhea, and constipation, particularly during dose escalation

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In the mitochondria, LC is converted to ALC, and balances the acetyl CoA/CoA ratio to maintain glucose metabolism through the TCA cycle, yielding a higher energy production [34]