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For decades it was avoided once kidney function dropped because of fear of lactic acidosis, but more recent data led the National Institute of Diabetes and Digestive and Kidney Diseases and the FDA to revise guidance
Typical cycle length is 8-12 weeks
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Woo JS, Kim W, Ha SJ, Kim JB, Kim SJ, Kim WS, et al
Coverage by Blue Cross Blue Shield varies by state, and specific plans, while Medicare Part D and Medicaid coverage depends on state guidelines
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