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A 2017 paper by Pickart and colleagues published in Brain Sciences (DOI: 10.3390/brainsci7020020) extended the gene expression analysis to nervous system function genes, relevant to the dense innervation of hair follicles and neural signaling in follicular cycling

Targeted delivery of copper(II) ions directly to target cells, GHK-Cu upregulates collagen type I and III synthesis, modulates matrix metalloproteinase (MMP) enzymatic activity, and stimulates endogenous antioxidant gene pathways in cell culture models