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[8] Once activated, these G-proteins may stimulate the production of second messengers like cAMP or IP3, which appear to act as secondary signaling molecules, potentially further propagating the signal within the cell
This occurs because oxidative stressors and toxic substances constantly affect the liver
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Naunyn Schmiedebergs Arch Pharmacol 2020;393:591-601
In a study involving rats, prednisolone, a glucocorticoid, was found to increase the hepatic capacity for urea-N synthesis (CUNS) and elevate the expression of urea cycle genes, which contributes to nitrogen loss
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