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Metabolic responses induced by compression of chondrocytes in variable-stiffness microenvironments
In clinic settings, emergency measures (like epinephrine and antihistamines) should be readily available in the rare event of an allergic reaction
In this cells, the apoptotic pathway relied upon the same Trx1/p38MAPK/p53 signaling axis and cell survival to diamide relied upon redox activation of NE2FL2, in a way independent of Keap1 oxidation, but responsive to ERK1/2 activation (Filomeni et al., 2012)
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To further validate our transcriptomic findings at the protein level, we assessed expression of key enzymes involved in glutathione biosynthesis, including GCLC, GCLM, and GLRX ( Figures 6E - G )
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