The potential role of adjunctive bone-protective therapies - including calcium and vitamin D supplementation, weight-bearing exercise, and, in selected high-risk cases, pharmacologic agents such as bisphosphonates - should be considered on an individual basis, though no evidence specifically addresses this question in MC4R -deficient patients
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Always monitor for new symptoms and consult your doctor
If symptoms are persistent or significantly restrict dietary intake, referral to a registered dietitian should be considered to ensure nutritional needs continue to be met
Bonsoir Docteur Picovski
If truly non-responsive to GLP-1 therapy, non-GLP-1 alternatives like phentermine-topiramate or the upcoming amylin-based therapies work through different mechanisms that may be more effective for your specific biology