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Even though developing a vaccine against GPNMB positive cells seems to be beneficial, the challenge remains to only deplete cells with the highest expression of the protein but not the cells expressing it at a physiological level 63

doi:10.1016/0014-5793(88)80509-X

It also downregulated the extracellular signal-regulated kinase-1/2 (ERK1/2), phospho-ERK1/2 expression, p53, and Bcl2-associated X protein (Bax) and upregulated Bcl-2 expression [63]

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