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In analyses excluding individuals with no BMI information and using imputation for BMI missing values, respective HRs were 0.89 (95% CI 0.26, 3.14) and 1.29 (95% CI 0.42, 3.92)

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It seems that the effects primarily mediated by GLP-1R and subsequently via the PKA/MAPK signaling pathway

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Managing Nausea, Constipation, And Fatigue Nausea, constipation, and fatigue are among the most reported side effects of GLP-1 agonists

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What has been shown in humans is the outcome rather than the mechanism

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