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doi: 10.1094/MPMI-03-22-0063-R 13 Diaz-VivancosP.WolffT.MarkovicJ.PallardF

This signaling cascade occurs primarily through the PI3K/AKT/mTOR pathway

Downstream effects include PI3K/Akt signaling, MAPK/ERK activation, and effects on actin cytoskeleton dynamics

4.7 Rheumatoid Arthritis (RA) RA is a highly prevalent disease with a complex, not yet fully understood etiology that is characterized by auto-Abs and excessive production of proinflammatory cytokines (including tumor necrosis factor-alpha, IL-1, IL-2, IL-6, IL-8, IL-17, interferon-gamma, receptor activator of NFB ligand, and granulocyte macrophage-colony stimulating factor)

Its molecular formula is C 14 H 22 CuN 6 O 4 , with a molecular weight of 401.9 g/mol and CAS number 89030-95-5

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