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Cerezyme was originally approved in 1994

Tirzepatide has two theoretical advantages for fibromyalgia: greater overall metabolic correction (especially insulin sensitivity) and additional neuroprotective effects through GIP receptor activation

Its practical advantage over earlier quinolinium analogues is permeability

Biochem Pharmacol 164:3444 Pereira M, Jeyabalan J, Jorgensen CS, Hopkinson M, Al-Jazzar A, Roux JP, Chavassieux P, Orriss IR, Cleasby ME, Chenu C (2015) Chronic administration of glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice

This framing matters

Setty, B