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Since then, a number of triple agonists have entered clinical development, with one in phase three clinical studies but have yet to reach the market (Capozzi, DiMarchi, Tschp)
GLP-1 receptor agonists provide significant reductions in HbA1c, weight loss, and cardiovascular benefits, making them highly preferred by clinicians for long-term management
Cell Rep (2020) 33(10):108487
While the complete results of the study have not yet been published, an initial press release in 2024 indicated that tirzepatide reduced the relative risk for the composite endpoint (HF urgent visit or hospitalization, oral diuretic intensification, or cardiovascular death) by 38%
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