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Journal of Environmental Quality
32,33 Moreover, immune checkpoint upregulation (PD-1, CTLA-4, TIGIT, LAG-3) and suppressive signaling cascades such as PTEN lossPI3K/AKT hyperactivation exacerbate T-cell dysfunction and resistance to ICIs
When PTT and OC/PF were used in combination, they exhibited antibacterial effects by promoting cell migration and angiogenesis
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Given the frequent co-occurrence of TP53 heterozygous deletion in RPS15 -mutant CLL, we also monitored three additional cohorts of mice with heterozygous Trp53 deletion ( Rps15 WT / Trp53 del [hereafter Trp53 del ], Rps15 Het / Trp53 del and Rps15 Hom / Trp53 del [hereafter combined, Rps15 MT / Trp53 del ], n = 30 each)
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