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There is a risk of hypoglycemia during titration of basal-plus and basal-bolus regimens, and patients should be made fully aware of this risk and any reported symptoms correlated with blood-glucose logs
They're not necessarily indicators of intolerance but rather evidence of pharmacological activity
doi:10.1016/B978-0-12-409527-4.00024-9 Estvez-Vzquez, O
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