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While tirzepatide has yet to demonstrate direct cardiovascular risk outcomes in patients without type 2 diabetes, tirzepatide-treated groups did demonstrate reductions in cardiometabolic variables resulting in a significantly lower 10-year predicted ASCVD risk in patients with overweight or obesity without type 2 diabetes in post hoc analysis of the SURMOUNT-1 trial [49]

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Figure 3 In another study comparing the neuroprotective effects of two other novel GLP-1/GIP dual receptor agonists (DA-JC4, DA-CH5) with the GLP-1 single receptor agonist liraglutide and the first-generation GLP-1/GIP dual receptor agonist DA-JC1 in MPTP-induced PD mice, the results concluded that the new dual receptor agonists have clear neuroprotective effects (112)

Eighty-three percent crossed the 15% mark

11 untreated) patients, in whom a 72-hour i.v

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