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Women of childbearing potential should use effective contraception during treatment and for at least 2 months after the last dose
These medications should not be used if you have a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
Even at lower doses such as a 25 mg dose of Spironolactone, often seen as a starting point in treatment regimens, it offers significant therapeutic benefits while minimizing potential side effects
G6PD deficiency causes increased susceptibility of erythrocytes to H2O2 and other reactive oxygen species that can lead to haemolytic anemia, favism, chronic non-spherocytic hemolysis, spontaneous abortions, and neonatal hyperbilirubinemia resulting in neonatal kernicterus
Fu et al., 2013)
JAMA Surg 159(6):660667
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