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These drugs work by boosting insulin (which lowers blood sugar), reducing a hormone called glucagon (which raises blood sugar), slowing down digestion, curbing appetite, and helping people lose weight
In the emulation of SURPASS-CVOT comparing tirzepatide to dulaglutide in patients at high cardiovascular risk (Table 2 and Supplementary Table 19), the estimated HR was 0.83 (95% CI 0.69 to 1.01) compared to the trial estimates of HR 0.92 (95% CI 0.83 to 1.01)
The same paper also included a nested case-control component of 120,054 patients with T2DM followed for 7.4 years and observed a lower association between dementia and exposure to GLP-1RAs compared with other antidiabetics 39
[12] GHRP-2 as a Diagnostic GH-Stimulation Agent Here the evidence tier becomes concrete and, importantly, honest