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In participants followed for a mean of 19 years, all-cause and cardiovascular disease mortality were 16% and 8% lower, respectively, per 1 mL/min/kg FFM higher cardiorespiratory fitness [33]

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McKenzie, A.L., Athinarayanan, S.J

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Schedule a GP appointment if: You have experienced no weight loss for several weeks despite documented adherence to dietary, activity, and medication recommendations You have developed new or worsening side effects You have concerns about continuing treatment You have developed new symptoms or medical conditions that may affect weight Seek urgent medical attention if you experience: Severe, persistent abdominal pain (with or without vomiting) which could indicate pancreatitis Symptoms of gallbladder disease such as pain in the upper right abdomen, fever, or yellowing of the skin/eyes Significant dehydration from persistent vomiting or diarrhoea Your GP can conduct a comprehensive medication review to identify any newly prescribed drugs that may contribute to weight gain or plateau, such as certain antidepressants, antipsychotics, corticosteroids, or diabetes medications

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If melatonin appears ineffective, several factors should be evaluated before concluding that the treatment is unsuccessful

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