The team noted a significant reduction in the excretion of N-methylhistidine, an indicator of muscle protein breakdown
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Packaging is designed to protect the lyophilized peptide from light and moisture exposure during transit, since both can affect peptide stability prior to use
Additional genetic polymorphisms occurring in choline and one-carbon metabolic pathways may alter the dietary requirement for choline and thus increase the likelihood of developing signs of deficiency when choline intake is inadequate (9, 20, 21)
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Commercial translation of this technology is exemplified by PureTech Health (founded 2001), which leverages MEVs within its preclinical Discovery platform for oral delivery of biologics (e.g., antisense oligonucleotides) and complex small molecules targeting rheumatoid arthritis, diabetes, autoimmune disorders, and oncology (Munagala et al., 2016