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Int J Mol Sci 23:4075

PYY(3-36) predominantly acts through the Y2 receptor (Y2R) in the hypothalamus to suppress appetite and in peripheral tissues (adipose, skeletal muscle, liver) to enhance insulin sensitivity

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In a 26-week Phase 2 obesity trial, cagrilintide 4.5mg produced a mean body-weight reduction of 10.8%, versus 3.0% on placebo and it outperformed liraglutide 3.0mg (10.8% vs 9.0%)[1]

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Liu X, Guo P, Liu A et al (2017) Nitric oxide (NO)-mediated mitochondrial damage plays a critical role in T-2 toxin-induced apoptosis and growth hormone deficiency in rat anterior pituitary GH3 cells