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Drinking plenty of water, eating balanced meals, and avoiding too much caffeine or alcohol can help

Since mitochondrial oxidative phosphorylation depends on local NADH availability, whereas cytosolic NADPH supports reductive buffering, disproportionate redistribution between compartments may amplify localized redox imbalance even when total cellular NAD levels appear preserved

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Most people get enough vitamin B12 in their diet, but some need supplementation