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In gastroparesis, NO signaling is often impaired, particularly in the loss of neuronal nitric oxide synthase (nNOS)-expressing neurons in the gastric wall
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Patients with comorbidities could safely use this treatment
These cells express high levels of PPAR receptors, and the effect of pioglitazone has been validated in vitro
they are active participants in its production and recycling
However, most standard protocols using subcutaneous administration follow the lower dosing ranges outlined above
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