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Dermoscopy may show brown or black globules, homogeneous or irregular lines, zigzag lines, proximal periungual pigmentation resembling Hutchinson sign, and distal fibrillar brush pigmentation (Fig
252 The NICD then translocates into the nucleus, where it forms a transcriptional complex with RBP-J and Mastermind-like (MAML) coactivators, activating downstream targets such as Hes, Hey, c-Myc, and Bcl-2
G-protein signaling (inside the cell)
Excessive heat accelerates degradation of the active ingredient and may compromise efficacy
Promotes tissue regeneration pathways
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