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[8] With advancing age, there is a decline in proteasome activity in cardiac tissue, which represents a significant mechanism contributing to the increased susceptibility of older organisms to cardiovascular diseases

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Results Impaired epithelial GPX4 activity features CD To investigate a role of reduced GPX4 activity and LPO in human IBD, we analyzed biopsy-derived IEC-enriched specimens from the lesional and non-lesional mucosa of CD and ulcerative colitis (UC) patients with active disease

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Interestingly, under iron-rich conditions and in the absence of host influences, iron has adverse effects, including a decrease in beneficial microorganisms and an increase in bacterial metabolite levels, which in turn impairs the barrier function of intestinal epithelial cells [73]