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It is important to emphasize the distinction between promising rodent studies and clinical relevance in humans
It has been investigated for its potential involvement in regulating sleep patterns, neuroendocrine function, and stress-related hormone signaling
It is a glucagon-like peptide-1 (GLP-1) agonist, which mimics the GLP-1 hormone
Phase 2 dose-finding trial (Lancet 2021) showed clear dose-response from 0.3 mg up to 4.5 mg/week, but 2.4 mg is the dose Novo Nordisk advanced into Phase 3 and is the most commonly self-reported community ceiling
Yue, F., Zhang, L., Jing, W., Ying, Z
Despite this, the Rare Disease portfolio provides key medical care, focusing on highly specialised therapies for hemophilia, growth hormone deficiency and hormone replacement, areas where patient populations are much smaller
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