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No dose-escalation or maximum tolerated dose studies have been conducted, limiting understanding of safety at higher doses

(This may be an important factor in endurance horses fed high grain diets)

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Some community members are running this sequence deliberately: start with NAD+ precursors (NMN/NR) to raise the baseline pool, then add MOTS-C to put that pool to work, then layer in 5-Amino-1MQ to block the pathway that drains it

Studies show that increasing B12 doses can help with neuropathyas seen in research

[3] A 2018 follow-up study further characterized 5-Amino-1MQ in cell-based assays and reported the following selectivity profile against other methyltransferases and related enzymes at concentrations up to 600 M: no detectable inhibition of DNMT1, PRMT3, or NAMPT