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Moreover, TMAO can cross the BBB
The evidence is pharmacokinetic and practice-based, not controlled outcome evidence
DSIP Pen: Restful Sleep & Stress Recovery DSIP to promote deep, restorative sleep and support stress adaptation
de Paiva Loureno LF, Suano-Souza FI, Fonseca FLA, et al
W.YuanY.FuY.WangP.et al (2021)
this is described as a loading phase
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