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Metamucil increases stool bulk and water retention, which can stimulate bowel movement activity
Weight loss reduces the mechanical load on bones, which can lead to lower bone density and, in some people such as those who are postmenopausal, as well as people over age 65 an increased risk of fracture
and Vidmar et al., who demonstrated initial efficacy but variable long-term responsiveness to GLP-1 therapies [18, 33]
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