They have also reported the synthesis of amphiphilic micelles with lipase-cleavable ester linkage for encapsulating and releasing dexamethasone, curcumin, nimodipine, and Nile red (Fig
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Further, 117 or 12 scans were accumulated for the samples with microsomes or whole cells, respectively
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While initial clinical observations indicate promising effects in specific conditions such as diabetic peripheral neuropathy, irritable bowel syndrome, and idiopathic intracranial hypertension, rigorous clinical trials are needed to confirm their efficacy, elucidate weight-loss-independent mechanisms, and establish comprehensive safety profiles across various pain conditions
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