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Restraining Akt1 phosphorylation attenuates the repair of radiation-induced DNA double-strand breaks and reduces the survival of irradiated cancer cells

R., Schuster, B., Moscucci, M

At minimum: baseline IGF-1, fasting glucose, HbA1c, comprehensive metabolic panel, and a full hormone panel

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Clinical trials showed modest fat loss of roughly 2-3 kg over 12 weeks, and the compound was never approved as a pharmaceutical because efficacy did not meet the threshold for drug registration (Heffernan et al., 2001)

Weight Loss: A lack of the B12 vitamin can cause the inefficient conversion of protein and fat into energy